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September 1948


Arch Intern Med (Chic). 1948;82(3):251-262. doi:10.1001/archinte.1948.00220270036003

IN 1944 MacLagan1 introduced the thymol turbidity test for diagnosis of diseases of the liver. With this test it should be possible to distinguish between hepatitis, obstructive jaundice and hepatic cancer. The thymol turbidity test has since been analyzed by various investigators (Watson and Rappaport,2 Hawkinson and Giebenhain, Shank and Hoagland,3 Kunkel and Hoagland,4 Lehmann,5 Maizels,6 Havens and Marck7 and Brante8). In conformity with MacLagan these investigators observed the reaction to be positive in about 90 per cent of cases of acute hepatitis and as a rule positive in chronic hepatitis, whereas it was rarely observed to be positive in cases of obstruction of the bile duct and hepatic cancer.

The thymol turbidity test is a flocculation reaction on certain plasma proteins. The flocculation occurs by means of a saturated thymol solution at pH 7.8. The turbidity is read in Pulfrich's photometer against a barbital buffer solution with thymol. The

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