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Article
October 1948

PERIPHERAL NEURITIS IN PERIARTERITIS NODOSAA Clinicopathologic Study

Author Affiliations

Fellow in Medicine, Mayo Foundation; ROCHESTER, MINN.

Dr. Kernohan is from the Section on Pathologic Anatomy, Mayo Clinic.

Arch Intern Med (Chic). 1948;82(4):321-338. doi:10.1001/archinte.1948.00020040001001
Abstract

NEURITIS in periarteritis nodosa occurs more frequently than is commonly supposed. In the original description of the disease by Kussmaul and Maier1 in 1866, the neurologic manifestations were prominently portrayed. It is somewhat surprising, then, that the clinical and pathologic aspects of involvement of peripheral nerves in periarteritis nodosa have received so little attention. Clinically, the role of peripheral neuritis has been difficult to assess because of the confusion which has arisen concerning the interpretation of purely subjective symptoms in a disease also characterized by arthritis and myositis. Pathologically, the chief drawbacks to a more complete understanding have been the infrequency of removal of peripheral nerves at autopsy and the difficulty in drawing conclusions from the study of only a small portion of a nerve.

REPORTS IN THE LITERATURE  The reports of peripheral neuritis in periarteritis nodosa are, for the most part, widely scattered in the literature and total

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