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December 1948

ACQUIRED ACUTE HEMOLYTIC ANEMIA OF UNKNOWN CAUSEReport of a Case with Fibrinoid Arteritis, Atypical Pneumonia and Lower Nephron Nephrosis

Arch Intern Med (Chic). 1948;82(6):578-587. doi:10.1001/archinte.1948.00220290062004

The RATHER scanty data on the lesions of acute hemolytic anemia have been reviewed recently by Damashek and Schwartz1 and may be summarized briefly. Of 29 cases in which histologic changes in the spleen were described, hyperplasia of reticular or histiocytic cells with giant cell formation, erythrophagocytosis and myeloid metaplasia was prominent in 12; multiple infarction with thrombosis of veins and capillaries, in 6, and extreme hyperemia of the pulp, said to be similar to that in congenital hemolytic icterus, in 11. The spleens were enlarged from one and one-half to six times. Bone marrow was described as showing normoblastic hyperplasia in a few cases. Of the 10 necropsies in which the liver was examined hemosiderosis was noted in all but 1, which showed acute yellow atrophy. "Hemoglobinous infarcts" were described in a case in which a lethal reaction to transfusion had occurred.

The present case is reported partly

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