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Article
April 1949

ANTIBODY RESPONSE IN PATIENTS WITH HYPOPROTEINEMIA: With Special Reference to the Effect of Supplementation with Protein or Protein Hydrolysate

Author Affiliations

With the Assistance of L. ASHBY ADAMS, M.D.; THOMAS HARVEY, M.D.; MOSES FRANCIS, M.D., and GEORGE CLOUGH PHILADELPHIA

From the Medical Services, Division of Chemistry and Division of Bacteriology, Philadelphia General Hospital.

Arch Intern Med (Chic). 1949;83(4):402-415. doi:10.1001/archinte.1949.00220330042006
Abstract

IMMUNITY is dependent in part on antibody production. There is ample evidence that antibodies are globulins modified in response to the presence of an antigen.1 Antibody globulins, like other plasma proteins and body proteins as well, are derived from dietary protein and thus depend for their formation on protein intake adequate in quality and quantity.2 Furthermore, the fundamental studies of Cannon and his co-workers3 and of others4 have shown that antibody production is lessened when hypoproteinemia is produced in experimental animals. Wissler and others5 demonstrated that protein repletion is associated with improved antibody response. The degree of protein depletion required to impair production of antibodies in animals was rather drastic in many of the experiments cited, and the relative importance of their observations as they relate to human antibody response has been challenged.6

Because of the clinical implications of these experimental studies, we have (1) investigated production of antibodies in

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