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Article
June 1949

RADIOACTIVE ISOTOPES IN THE STUDY OF PERIPHERAL VASCULAR DISEASEI. Derivation of a Circulatory Index

Arch Intern Med (Chic). 1949;83(6):608-619. doi:10.1001/archinte.1949.00220350018002
Abstract

THE APPLICATION of a new investigative tool in medical research is an exciting experience. Old concepts and barriers to new ideas crumble, and new avenues of approach to the understanding and solution of previously impenetrable problems appear. We are reporting on the use of radioactive isotopes in the investigation of peripheral vascular diseases, especially arteriosclerosis obliterans. The gradual aging of the population has increased the incidence of arteriosclerosis and its complications and will undoubtedly continue to do so. One such factor, recently enunciated, has been the progressive development of obliterative vascular diseases in diabetic patients, whose lives have now been prolonged by approximately a generation through the judicious use of insulin. The frequent occurrence of advanced vascular disease among patients at Cook County Hospital and the resulting necessity for amputations prompted this investigation. In the past several years, a number of reports1 have appeared on the use of various

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