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June 1949


Author Affiliations


From the Department of Pathology, Queens General Hospital.

Arch Intern Med (Chic). 1949;83(6):665-676. doi:10.1001/archinte.1949.00220350075006

EVER since 1700, when Bonetus1 first demonstrated the correlation of dyspnea, sudden death and calcified coronary vessels, the study of disease of the coronary arteries has commonly been related to the study of severe symptoms in the patient. It remained for Herrick,2 as late as 1912, finally to present a complete clinical description of the syndrome of sudden occlusion of the coronary arteries. Little was accomplished in the evolution of this important medical concept in the interval between these two dates. The delay constitutes one of the remarkable facts in medical history.

Up to the present time, it has almost universally been presumed that some combination or variation of the classic symptoms of pain, shock, dyspnea and cardiac failure is present in each case of myocardial infarction in which a considerable portion of the myocardium is involved.3 The symptom of pain in myocardial infarction is conceded

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