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Article
August 1949

Investigations into the Development of the Pituitary and Hereditary Anterior Pituitary Dwarfism in Mice.

Arch Intern Med (Chic). 1949;84(2):357-358. doi:10.1001/archinte.1949.00230020160012

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Abstract

This monograph by Torben Francis has been translated from the Danish. Its object is to study the development of the adenohypophysis in mice with hereditary anterior pituitary dwarfism. The work of other investigators of the anterior pituitary lobe in the experimental animal and in the human being is reviewed in detail. In 1929 Snell found dwarfism in a strain of mice. This strain has been studied extensively, particularly with reference to the pituitary gland. Two hundred fetuses and young of this strain of mice constitute the material for the experimental study. They were killed after the age of 9 fetal days, by which time the anlage of the anterior pituitary lobe is developed, to the age of 12 days after birth, when the dwarf growth manifests itself. In addition, the pituitary glands of older mice which were dwarfs and some which were normal were studied. All the histologic observations on

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