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September 1949

CLINICAL AND BIOCHEMICAL STUDY OF REMISSIONS IN NONSPECIFIC ARTHRITIS: From the Medical Department and the Pathological Laboratories, Bronx Hospital.

Arch Intern Med (Chic). 1949;84(3):361-378. doi:10.1001/archinte.1949.00230030003001

IT IS WELL known that nonspecific arthritis is a disease which is characterized by relapses and remissions.1 It is also generally accepted that whereas there is no specific curative agent for this disease, there are many measures which hasten remissions in both rheumatoid arthritis and osteoarthritis.2 As Hench3 recently stated in discussing the use of gold therapy in rheumatoid arthritis, a remission may be obtained by this method in six months in a case in which it otherwise might require six years. Using measures other than chrysotherapy, a smaller percentage of remissions has been reported after the use of such diverse treatments as hyperthermia with typhoid vaccine,4 hypervitaminosis with massive doses of activated ergosterol (viosterol),5 bismuth therapy,6 low carbohydrate diets,7 administration of cinchophen,8 starvation,9 administration of streptococcus vaccine,10 administration of foreign protein,11 bee venom therapy12 and even anesthesia.13

Of striking significance is the fact that the highest percentage of remissions

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