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September 1949

PERNICIOUS ANEMIA IN EARLY ADOLESCENCE: Report of a Case in a Girl of Fourteen

Author Affiliations


From the Department of Internal Medicine, State University of Iowa College of Medicine.

Arch Intern Med (Chic). 1949;84(3):445-448. doi:10.1001/archinte.1949.00230030087008

PERNICIOUS anemia is a disease of late adult life, rarely being encountered in patients under 30, and is exceedingly infrequent in children. Doubt has been expressed in many texts and articles as to whether true pernicious anemia ever occurs in infancy or childhood. A pernicious anemia-like disease, i. e., a macrocytic anemia with megaloblastic arrest of the bone marrow, may occur with Diphyllobothrium infection, syphilis, various gastrointestinal lesions, steatorrhea, or other conditions in which there is improper absorption or production of the maturation factor.1 The commonest cause of macrocytic anemia in childhood is probably a diet deficient in the extrinsic factor. There have been many reports of pernicious anemia occurring in children, but the diagnosis was open to question in most cases, and Wintrobe1b accepted only 2 cases with certainty. Peterson and Dunn,2 in 1946, reviewed the literature on the subject; they accepted only 2 cases3

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