DEVELOPMENT OF MODERN CONCEPTS OF THROMBUS FORMATION
IN THE first half of the nineteenth century, thrombosis of blood vessels was held to result either from excessive coagulability of the blood or from exudative inflammation of the vascular wall. Virchow's views1 influenced subsequent thought on the subject of intravascular clotting by their stress on the importance of slowing or stagnation of blood flow as well as on altered "molecular attraction" between the blood and the vascular wall.By means of experiments in living animals, Mantegazza2 (1869, 1871) and Zahn3 (1875) assembled proof that thrombosis is not equivalent to simple clot formation but consists primarily in a process of selective precipitation of protoplasmic elements from the flowing blood at sites of vascular injury to form a homogeneous, grayish white deposit (the "white thrombus"). With complete occlusion of the lumen by the white thrombus, the blood which is trapped in
MOOLTEN SE, VROMAN L, VROMAN GMS, GOODMAN B. ROLE OF BLOOD PLATELETS IN THROMBOEMBOLISM. Arch Intern Med (Chic). 1949;84(5):667–710. doi:10.1001/archinte.1949.00230050003001
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