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November 1949

DEFECT OF THE VENTRICULAR SEPTUM: Summary of Twelve Cases and Review of the Literature

Author Affiliations


From the Departments of Medicine and Pathology, Stanford University School of Medicine, and the San Francisco Hospital (Department of Public Health, City and County of San Francisco).

Arch Intern Med (Chic). 1949;84(5):798-823. doi:10.1001/archinte.1949.00230050134007

UNCOMPLICATED defects in the interventricular septum are among the earliest of the congenital cardiac malformations to be recognized clinically. Henri Roger presented a remarkably accurate clinical description of this syndrome in 1879,1 and the name maladie de Roger is frequently used in connection with defects of the ventricular septum. Roger's presentation was in the form of a clinical lecture without the benefit of illustration by an autopsy. In spite of an abundance of reports on single cases of defect of the ventricular septum, no series was collected until 1920, when Müller2 reported 9 cases and gave a brief review of case reports collected from the literature; the paper was presented in a somewhat sketchy and unsystematic manner.

The basic information about the pathologic features and the clinical picture of defect of the ventricular septum was contained in Maude Abbott's monograph3 and was based on her well known