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December 1949

PERIARTERITIS NODOSA: Study of Chronicity and Recovery, with Report of Two Cases

Author Affiliations


From the Fifth and Sixth (Boston University) Medical Services, Boston City Hospital.

Arch Intern Med (Chic). 1949;84(6):983-1001. doi:10.1001/archinte.1949.00230060140011

THE PURPOSE of this communication is to reevaluate the prognosis in periarteritis nodosa in the light of the reports in the literature and the personal experiences noted herein. In the past, the course of the disease has been regarded as leading to a fatal termination. This, undoubtedly, is the outcome in the majority of instances. There have been cases, however, in which the disease has taken a chronic course, others with long, complete remissions and a few in which recovery has been reported. Two cases in which recovery occurred are presented.

In 1852, von Rokitansky1 first described the pathologic changes of the disease entity periarteritis nodosa. It remained for Kussmaul, however, to recognize it as a clinical syndrome. With Maier,2 in 1866, he reported 2 cases of a "hitherto undescribed peculiar disease of the arteries which is accompanied by Bright's disease and is a rapidly progressive, general paralysis