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March 1950

LOWER NEPHRON NEPHROSIS: Report of Treatment of Forty-Four Patients by Repeated Replacement Transfusions

Author Affiliations


From the National Tranfusion Center 53, Boulevard Diderot.

Arch Intern Med (Chic). 1950;85(3):416-431. doi:10.1001/archinte.1950.00230090053004

TWO THERAPEUTIC methods were recently recommended for the treatment of patients with acute azotemia, utilizing dialysis to remove nitrogenous waste from the blood. The machine which performs dialysis through cellophane® tubing (the artificial kidney) was invented in Holland by Kolff1 and independently in Canada by Murray and others.2 Dialysis of nitrogenous waste through peritoneal membrane (peritoneal irrigation) was used successfully in human beings by Fine, Frank and Seligman.3

These methods, though brilliant, do not entirely solve the problem. The use of replacement transfusion, with or without the additional aid of various methods of dialysis, has in my experience proved of more value in these cases.

Abbel, Rowntree and Turner3a employed plasmapheresis in animals. Gilbert and Tzanck3b used the same technic in patients with uremia, twenty-five years ago, in 1925.

Replacement transfusion was carried out experimentally in dogs by Tzanck, Bessis and Burstein.4 It was proposed as a treatment of