[Skip to Content]
[Skip to Content Landing]
March 1950

SYPHILIS: A Review of the Recent Literature

Author Affiliations


Arch Intern Med (Chic). 1950;85(3):496-541. doi:10.1001/archinte.1950.00230090133011

CEREBROSPINAL FLUID  The cerebrospinal fluid examination has assumed added importance with the advent of penicillin therapy. Whether one should rely on changes in the spinal fluid alone or on a combination of the fluid and clinical changes has not been settled, and there are syphilologists and neurologists who favor both sides. Dattner,98 of Bellevue Hospital, New York, is one who relies largely on the changes in the cerebrospinal fluid. He believes that in neurosyphilis evaluation the results of examination of cerebrospinal fluid offers additional information as to the character of the underlying processes. Of especial value are the cell count, determination of total proteins, and colloidal mastic test.Pleocytosis is indicative of activity of the pathologic processes in the nervous system. Arrest of the syphilitic process is quickly followed by a return of the cell count to normal and occurs in all successfully treated patients.