[Skip to Navigation]
April 1950

RADIOACTIVE ISOTOPES IN THE STUDY OF PERIPHERAL VASCULAR DISEASE: III. Further Studies on the Circulation Index with an Evaluation of the Diagnostic and Therapeutic Value of Priscoline®

Author Affiliations


From the Hektoen Institute for Medical Research of the Cook County Hospital and the Peripheral Vascular Clinic, Mercy Hospital.

Arch Intern Med (Chic). 1950;85(4):667-674. doi:10.1001/archinte.1950.00230100124002

THE CONDITION of the peripheral vascular circulation can be estimated by means of radioactive isotopes. A method in which radioactive phosphorus is used to test the status of the peripheral circulation has been described.1 Data so obtained not only afford a survey of circulatory efficiency but can be helpful as a guide to prognosis and treatment. The method is applicable to the investigation of new drugs designed to treat peripheral vascular disease. This report is concerned with some observations on the use of 2-benzylimidazoline hydrochloride (priscoline®),2 whose effect occurs chiefly at the termination of the sympathetic nerves in the vascular smooth muscle. It may also have a direct histamine-like effect on the smaller vessels.3 According to Wirsa and Ottoman,4 the action of the drug is complex, causing peripheral vasodilatation and increased cardiac output.

CIRCULATORY INDEX AS DETERMINED BY RADIOISOTOPES  Two hundred microcuries of radioactive phosphorus