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May 1950

IMMUNITY IN TULAREMIA: Report of Two Cases of Proved Reinfection

Author Affiliations


Arch Intern Med (Chic). 1950;85(5):777-782. doi:10.1001/archinte.1950.00230110052004

IT IS WIDELY accepted that patients who recover from initial attacks of tularemia are endowed with an immunity, the high quality and sustained activity of which is seldom encountered on recovery from any other bacterial disease. However, several textbooks1 go so far as to imply that recovery from the disease is followed by a lifelong absolute immunity with complete protection against reinfection. The purpose of the present article is to present evidence that reinfections do occur and to discuss the significance of such cases in the light of more recent experimental studies on immunity in tularemia.

Francis2 has recorded a single case in which four separate local reinfections were noted approximately two and one-half, three and one-half, thirteen and one-quarter and fifteen and one-half years after the original attack. Fever was absent in the first and third reinfections, but temperatures as high as 102.2 F. were recorded during