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May 1950

SYPHILIS: A Review of the Recent Literature

Author Affiliations


Arch Intern Med (Chic). 1950;85(5):819-886. doi:10.1001/archinte.1950.00230110094008


Penicillin in Benign Late and Visceral Syphilis.  —On the basis of a review of the literature and results in a series of 39 cases, Tucker220 concludes that results are satisfactory in approximately 90 per cent of cases of benign late syphilis following the administration of a single course of penicillin alone. Late benign syphilis is defined as "allergic in type, with chronic, focal inflammatory lesions involving structures not essential to life or vision, and which develop more than two years after infection." The most important types are benign late gummatous syphilis of skin, of mucous membranes and of bone. In the author's series of 39 cases there were 3 failures, while in a published series of 21 similar cases there were 2 failures, a gross failure rate of 8.3 per cent. There were no failures in 11 cases of patients treated