IN THE American medical literature of recent years, various authors have speculated on the relation in human beings of certain types of pancreatic disease to fatty change and portal cirrhosis of the liver.
In 1934 Zeckwer1 cited the case of a senile nondiabetic patient with pancreatic lithiasis, producing obstructive parenchymal atrophy, in whom the liver showed fatty change. The patient suffered primarily from carcinoma of the esophagus.
Three years later Snell and Comfort,2 with a detailed clinical description of 2 cases of pancreatic lithiasis and a brief summary of a third case, discussed the pancreaticohepatic relation. In the 2 patients whose cases were described in detail duodenal contents revealed an absence of pancreatic enzymes. There was enlargement of the liver with jaundice, ascites, steatorrhea and splenomegaly. The first patient was diabetic; he drank alcohol moderately; he improved on administration of lipocaic. The second patient did not have diabetes;
SANES S, MILLER DK, BRASON FW, GEIST OB. FATTY CHANGE AND CIRRHOSIS OF THE LIVER IN PATIENTS WITH PANCREATIC LITHIASIS. Arch Intern Med (Chic). 1950;85(6):980–997. doi:10.1001/archinte.1950.00230120089009
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