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June 1950

Contribucion del coeficiente citologico a la fisiología y patología de la correlación hipofisotiroidea.

Arch Intern Med (Chic). 1950;85(6):1010-1011. doi:10.1001/archinte.1950.00230120119011

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The book represents a summary of the author's own work on the pituitarythyroid axis. After a renumeration of some cytologic problems dealing with secretory phenomena of the thyroid gland, the Altman freezing and drying method of fixation, together with a description of apparatus and a few modifications thereof, is described. The formation of intracellular colloidal droplets was taken as the cytologic criterion for stimulation of the thyroid cell after administration of thyrotropin. Other criteria, such as clear vacuoles and chromophobic colloid, were considered artefacts.

Observations on the intracellular colloid were made on normal and on hypophysectomized frogs and rats and on normal guinea pigs and chicks. For use in assay, a cytologic coefficient was devised. The cytologic coefficient was defined as a number obtained by dividing the observed number of intracellular colloid droplets per follicle by the mean follicular diameter in millimeters. A series of doses of thyrotropin was tested,

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