THE ASSOCIATION of clubbing of the fingers with various disease states has interested physicians for many years. Little is known about the pathogenesis of this disturbance. Mendlowitz1 carefully analyzed all reports of the syndrome in 1942 and grouped all bilateral symmetric cases as acquired, hereditary or idiopathic. The acquired condition was associated with certain pulmonary, cardiac and gastrointestinal disorders and a rarely seen miscellaneous group of diseases. In this last classification was recorded a single case of cystopyelitis, but no other urologic aspects were discussed. The hereditary group was considered to be a separate entity, inherited as a mendelian dominant trait and therefore often affecting other members of the family. In these persons the clubbing appeared early in life, and its association with various diseases was, in Mendlowitz' opinion, simply coincidental. In the so-called idiopathic group a single case associated with urologic abnormalities was cited but not discussed. Mendlowitz
WARTHIN TA, COOPER JF, CAPUTI AP. CLUBBING OF DIGITS, METAPLASIA OF URINARY BLADDER AND MUCOUS DIARRHEA. Arch Intern Med (Chic). 1950;86(1):10–21. doi:10.1001/archinte.1950.00230130032002
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