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Article
July 1950

HEMOLYTIC ANEMIA WITH PAROXYSMAL METHEMOGLOBINEMIA AND SULFHEMOGLOBINEMIAReport of Two Cases

Author Affiliations

NEW HAVEN, CONN.; Director of Laboratories, Mount Sinai Hospital; MILWAUKEE; NEW YORK; Formerly Associate in Medicine, Peter Bent Brigham Hospital and Harvard Medical School; BOSTON

From the Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Buffalo General Hospital, University of Buffalo School of Medicine and the Mount Sinai Hospital, Milwaukee.

Arch Intern Med (Chic). 1950;86(1):22-34. doi:10.1001/archinte.1950.00230130044003
Abstract

THE FOLLOWING case reports deal with 2 patients, independently observed, who showed a combination of intracellular methemoglobinemia, sulfhemoglobinemia and hemolytic anemia. There are a few instances in the literature of the coexistence of these two abnormal pigments in the same patient.1 Although it must occur commonly after treatment with certain drugs,2 no well documented reports were found of the spontaneous occurrence of both hemolytic anemia and abnormal intracellular pigments. The present studies were undertaken to elucidate the mechanism of formation of the abnormal pigments in these patients and the possible relationship to excessive destruction of blood.

REPORT OF CASES 

Case 1.  —The patient, a 37 year old housewife, was admitted to the Peter Bent Brigham Hospital March 5, 1946 for the study of cyanosis of twenty-one years' duration.Although a premature baby, the patient was entirely normal in growth and development through puberty. She had had no illnesses

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