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July 1950


Author Affiliations


From the Department of Internal Medicine, University of Minnesota Hospitals and Veterans Administration Hospital.

Arch Intern Med (Chic). 1950;86(1):35-50. doi:10.1001/archinte.1950.00230130057004

SKELETAL defects due to localized or diffuse demineralization of bone are not infrequently the predominant features of a great variety of clinical diseases. The differential diagnosis of such conditions may present a difficult and complex problem. A broad classification of the diseases essential for consideration in such problems is given in table 1. It is readily evident that these diseases encompass a wide field of medical and surgical specialties. A further clinical difficulty arises from the current confusion regarding a group of skeletal diseases of unknown causation. Pseudocystic disease of bone is suggested as a suitable generic term to include this confusing array of clinical syndromes and proposed pathologic processes. Until comparatively recently, no common denominator for this group of diseases was apparent, but within the last few years a close relationship among Letterer-Siwe disease, Hand-Christian syndrome, eosinophilic granulomatosis and lipid granulomatosis (xanthomatosis) has been suggested.1 The clinical features