ALKAPTONRIA was recognized in clinical medicine as early as - the sixteenth century. It is true that the evaluation of the clinical findings had to wait for further investigation at a later date; yet the remarkable powers of observation of early workers are dramatically interesting. A descriptive passage by Garrod1 concerning a case reported by Lusitanus2 in 1649 is worthy of repetition.
The patient was a boy who passed black urine and who at the age of fourteen years was submitted to a drastic course of treatment which had for its aim the subsiding of the fiery heat of the viscera which was supposed to bring about the condition in question by charring and blackening his bile. Among the measures prescribed were bleedings, purgative baths, a cold and watery diet and drugs galore. None of these had an obvious effect and eventually the patient who tired of the futile
EISENBERG H. ALKAPTONURIA, OCHRONOSIS, ARTHRITIS AND RUPTURED INTERVERTEBRAL DISK: Complicated by Homologous Serum Reaction. Arch Intern Med (Chic). 1950;86(1):79–86. doi:10.1001/archinte.1950.00230130101006
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