SINCE the advent of antibiotics, the prognosis of subacute endocarditis has been improved greatly; nevertheless the disease is still fatal in about 50 per cent of patients. It is by no means a rare sickness, particularly in areas where rheumatic heart disease is common. Patients with subacute bacterial endocarditis will, in almost every case, have had either a preexisting lesion of one of the cardiac valves or a congenital cardiac deformity. The valvular lesion may have been caused by rheumatic fever, syphilis or arteriosclerotic changes and is often unknown to the patient. Lesions due to arteriosclerosis are of special importance because they are the nidus on which bacterial infection develops in older persons. The majority of patients, however, are between 20 and 40 years of age, the sexes being almost equally afflicted.
The commonest organism causing subacute bacterial endocarditis is Streptococcus viridans. When this organism causes a transitory bacteremia in
ROTH O, CAVALLARO AL, PARROTT RH, CELENTANO R. AUREOMYCIN IN PREVENTION OF BACTEREMIA FOLLOWING TOOTH EXTRACTION. Arch Intern Med (Chic). 1950;86(4):498–504. doi:10.1001/archinte.1950.00230160010002
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