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Article
October 1950

EFFECTS OF INTRAVENOUS INJECTION OF TYPHOID VACCINE ON BLOOD LEUKOCYTES AND ADRENAL CORTEX

Author Affiliations

BOSTON

From the Laboratory of Clinical Physiology, McLean Hospital, Waverley, Mass., and the Department of Medicine, Harvard Medical School, Boston.

AMA Arch Intern Med. 1950;86(4):505-518. doi:10.1001/archinte.1950.00230160017003
Abstract

THE OBSERVATIONS of Dougherty and White1 on the effects of pituitary adrenocorticotropic hormone on lymphoid tissue led these authors to review some of the earlier work on changes which occurred in the lymphocyte count in infections or after the injection of bacterial toxins; Dougherty and White1 concluded that the lymphopenia caused by bacterial toxins was a consequence of the action of adrenal cortex hormones. More recently, however, Lewis and Page2 cast doubt on this concept when they showed that adrenalectomy does not prevent the decrease in the number of blood lymphocytes which results from the injection of typhoid vaccine. On the other hand, there is histologic evidence that reactions to the injection of bacterial vaccines are associated with the same changes in the adrenal gland as are other forms of stress.3 In view of these discrepancies, it was considered of

interest to make studies of the blood leukocytes and of

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