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Article
October 1950

ADULT RENAL OSTEITIS FIBROSA WITH METASTATIC CALCIFICATION AND HYPERPLASIA OF ONE PARATHYROID GLAND: Report of a Case

Author Affiliations

Director of Laboratories, Greenville General Hospital; CHICAGO

From the Departments of Pathology and Orthopaedics of the Research and Educational Hospitals and the University of Illinois College of Medicine.

AMA Arch Intern Med. 1950;86(4):533-557. doi:10.1001/archinte.1950.00230160045005
Abstract

LONG-STANDING renal disease with accompanying hyperplasia of the parathyroid glands and osteitis fibrosa is a rare syndrome which only in recent years has been adequately described from the clinical and pathologic viewpoints with at least partial clarification of the pathogenesis. Because of its unusually interesting clinical and pathologic features, particularly in children, the disorder has formed the basis of a number of reports dealing with young persons. It is not appreciated so well, however, that a similar syndrome may occur in the adult.

Lucas1 in 1883 first noted the association of albuminuria and rickets, and Fletcher2 in 1911 described skeletal changes in children with long-standing renal dysfunction. The condition has subsequently been described under various designations, such as renal rickets and renal dwarfism. These children showed either decrease or cessation of growth, with skeletal deformities and enlargement of the bones at the endochondral junctions. Because of the similarity

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