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November 1950

LIVER AND BILIARY TRACT: A Survey of Tests for Hepatic Function; the Use of the Hepatic Star in the Differential Diagnosis of Jaundice

AMA Arch Intern Med. 1950;86(5):743-788. doi:10.1001/archinte.1950.00230170096008

INTEREST in the functions of the liver has grown apace with the development of practical tests and the demonstration of the clinical usefulness of these tests in the study of patients with jaundice or other forms of hepatic disease. One of the first reviews of the subject was that of Rowntree, Marshall and Chesney in 1914.1 My interest was initiated by a review published in 1925.2 The field has expanded greatly since then. The table shows some of the major developments.

It is obvious that this field has expanded so greatly that, at present, it is too complex to be surveyed in detail in any one review. This presentation, therefore, is divided into two parts. The first will be a survey of recent developments concerning tests for hepatic function. These selected tests will be discussed in detail. In the second part, I shall present my views on the clinical use