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December 1950

Thyroid Hormones and Their Action.

AMA Arch Intern Med. 1950;86(6):970. doi:10.1001/archinte.1950.00230180175013

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This absorbing little book is the chronicle of a lifetime spent in research on thyroid physiology. The author has devoted a great deal of his research to. various fundamental aspects of thyroid physiology. The first portion of the book is given to a study of experimental macrocytic anemia produced by various means in which the author demonstrates that in thyroidectomized animals it is necessary to give a thyroid fraction in addition to liver extract to produce remission. The thyroid fraction which is necessary is distinct from thyroxin, and the author terms this the "myelotropic" hormone.

With regard to thyroxin, the author cites an interesting series of experiments to prove that it reaches the peripheral organs by means of the peripheral nerves. It then exerts its typical known action on the end organs.

The last half of the book is devoted to the story of the isolation in crystalline form of

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