THE EFFECTS of therapy with pituitary adrenocorticotropic hormone (ACTH) and cortisone in rheumatoid arthritis have stimulated clinical trials of more readily available steroids and related compounds. Of this group, desoxycorticosterone acetate combined with ascorbic acid has been introduced relatively recently and because of its availability has already been tried in many centers throughout the world.
The first report of the use of combined desoxycorticosterone acetate and ascorbic acid was the preliminary communication of Lewin and Wassén1 in The Lancet of Nov. 26, 1949. The Swedish workers treated six women and three men with rheumatoid arthritis by administering 5 mg. of desoxycorticosterone acetate intramuscularly, followed within five minutes by the giving of 1,000 mg. of ascorbic acid intravenously. In all nine of their patients prompt improvement was reported, with almost complete subsidence of pain and definite increase in joint motility within 15 to 30 minutes. Improvement persisted from two to
McKENDRY JBR, SCHAFFENBURG CA, McCULLAGH EP. COMBINED ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE AND ASCORBIC ACIDI. Clinical Results in Rheumatoid Arthritis and Laboratory Studies. AMA Arch Intern Med. 1951;87(2):190–198. doi:10.1001/archinte.1951.03810020012002
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