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February 1951

Q FEVER IN CALIFORNIA: III. Aureomycin in the Therapy of Q Fever

Author Affiliations


From the Acute Communicable Disease Service and the Viral and Rickettsial Disease Laboratory, State of California Department of Public Health.

AMA Arch Intern Med. 1951;87(2):204-217. doi:10.1001/archinte.1951.03810020026004

AFTER THE observations of Wong and Cox1 that aureomycin was therapeuticallyeffective in experimental Q fever in the guinea pig, a study of the usefulness of this drug in the treatment of human Q fever was undertaken. Encouraging results in an initial group of 15 patients have been reported.2 Since that time a larger group of patients have been treated with aureomycin. The present report summarizes experience with this antibiotic over a period of one year in the treatment of Q fever in the 45 patients comprising these two groups.


Aureomycin-Treated Patients.  —In general, patients suspected of having Q fever were brought to our attention by physicians practicing in areas of the state where the disease appears to occur endemically or in epidemic form. With a few exceptions in which the cases chosen appeared as a part of localized outbreaks, the patients did not come to

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