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February 1951

SYPHILISA Review of the Recent Literature

AMA Arch Intern Med. 1951;87(2):287-322. doi:10.1001/archinte.1951.03810020109011

DURING the period covered by this fifteenth annual review of syphilis,1 July 1, 1949 to July 1, 1950, the reviewers have been impressed with the rather unspectacular character of the material available for analysis. However, a few items are worthy of emphasis. Chief among these are the studies of Delamater and his co-workers at the University of Pennsylvania, dealing with the possible life cycle of Treponema pallidum, an effort which, even in its early stages, shows great promise. Also, Scott's investigation of the use of hyaluronidase for syphilis is perhaps the most novel of recent applications of a general principle of bacteriology to syphilology.

Most of the other work on experimental syphilis concerns penicillin, although there is still active interest in serology, in the cardiolipin antigen, the spirochetal immobilization test and a projected serologic conference. In clinical diagnosis of syphilis angiocardiography has been established as a valuable tool in