THE DIAGNOSIS of Gaucher's disease (lipid histiocytosis of kerasin type) is made on the basis of the following typical findings: hepatosplenomegaly, wedge-shaped pingueculae in the conjunctivas, pigmentation on the lower part of the legs, bone lesions which tend to occur in the head, neck and lower end of the femurs and a normal blood cholesterol level. Most usually there are hypochromic anemia, leukopenia and thrombocytopenia. The diagnosis is made conclusive by demonstration of typical Gaucher cells, and this is easily done by sternal marrow aspiration.1
Potter and McRae described a case of Gaucher's disease treated with liver extract.2 Their patient was admitted with hypochromic anemia. No bone marrow studies were made. Because of macrocytosis, the patient received 3 to 4 vials of liver extract daily for 11 months. There was symptomatic improvement, and a decrease in skin pigmentation, pingueculae and spleen size occurred. The erythrocyte count returned to
KRIM M, SAWITSKY A, KROHN D, MEYER LM. GAUCHER'S DISEASE WITH MEGALOBLASTIC BONE MARROW: Response to Therapy. AMA Arch Intern Med. 1951;87(3):418–423. doi:10.1001/archinte.1951.03810030091008
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