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April 1951

ALLERGY—HISTAMINE AND ACTH: A Review of the Literature from August 1948 to September 1950

AMA Arch Intern Med. 1951;87(4):598-621. doi:10.1001/archinte.1951.03810040123010

IN THE LAST two years interest in the diseases of allergy centered for a time on the antihistaminic drugs, and then in May 1949 came the startling announcement by Hench and his co-workers1 that the adrenocorticotropic hormone of the pituitary (ACTH) would relieve all the symptoms of rheumatoid arthritis. Since the general problem of arthritis was not unlike the general problem of asthma, those interested in clinical allergy recognized at once that this remarkable agent might be useful for their patients also.

In the two years reviews of the literature on clinical allergy have been published, most of them dealing with one or another particular aspect, and they will be mentioned. Special thanks are due to Unger and Gordon2 for a remarkable summary of a vast number of recent papers in the field of clinical allergy up to the time of ACTH. Anyone interested in the details should

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