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July 1951

Toxicology of Uranium.

AMA Arch Intern Med. 1951;88(1):134. doi:10.1001/archinte.1951.03810070144017

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This is one of a series of approximately 60 volumes in which is recorded the declassified research work done on the Manhattan Project under the Atomic Energy Commission. It consists of eight chapters dealing with the toxicology of uranium and 16 additional papers of a more or less supplementary nature. It was compiled by 15 authors under the editorship of Dr. Tannenbaum. The papers discuss the absorption, transport, distribution and excretion of uranium, the action of uranium on various enzyme systems, etc., and give a good illustration of the modern technics involved in a survey of the hazards of both acute and chronic exposures to toxic agents.

Some uranium salts (uranyl nitrate, etc.) are highly toxic, while others (uranium oxide) are relatively nontoxic. In general, it appears that uranium is a less serious toxicological hazard than either mercury or lead and that the practice of good industrial hygiene should preclude

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