MORE than 30 years ago the proposal was made by Timme1 and others2 that the pathologic process in progressive muscular dystrophy was primarily endocrine. Critical review of this concept in the light of the clinical data now available and the meager metabolic data concerning such patients in the literature yields only tenuous support for it.3 Nonetheless, in initiating a long term study of the disorder, it seemed desirable to reevaluate this thesis with the aid of some of the more recently developed, as well as the older, clinical signs and laboratory tests of endocrine function.
In addition to these studies of endocrine function, a number of other determinations related to metabolic processes have been carried out. The levels of serum protein have been determined and the serum proteins fractionated into various components by chemical and physical means. Meldolesi4 and Stefanutti5 claimed that there is present
TYLER FH, PERKOFF GT. STUDIES IN DISORDERS OF MUSCLE: VI. Is Progressive Muscular Dystrophy an Endocrine or Metabolic Disorder? AMA Arch Intern Med. 1951;88(2):175–190. doi:10.1001/archinte.1951.03810080043005
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