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November 1951

SUBCLINICAL INFECTIOUS MONONUCLEOSIS WITH HEPATITIS: Epidemic in a Class of One Hundred Two Medical Students; A Two-Year Study

Author Affiliations


From the Departments of Medicine and Microbiology, State University of New York at New York City, College of Medicine, and the Department of Chemistry, Maimonides Hospital, Brooklyn.

AMA Arch Intern Med. 1951;88(5):618-626. doi:10.1001/archinte.1951.03810110070007

THE HIGH prevalence of infectious mononucleosis, especially among the school and army population and young medical personnel, is well attested to by a voluminous literature on the subject.1 In addition to sporadic cases, numerous clinical epidemics have been reported since the first description by West2 in 1896 of one in a community in Ohio. However, Halcrow,3 in a study of an epidemic of 296 cases in an Emergency Medical Service Hospital in Scotland in 1942, was the first to emphasize the occurrence of cases with hematoserologic evidences of infectious mononucleosis without the usual clinical manifestations. Vander Meer and associates4 found 340 subclinical cases in an army camp in Wisconsin within a five-month period. Wechsler and associates5 reported an epidemic in an army post in Texas of 556 cases, of which 112 lacked clinical findings. Since infectious mononucleosis is not usually reported to public-health authorities, its