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November 1951

NONSPECIFIC GRANULOMA OF RECTUM AND SIGMOID COLONLesions of Rectum and Sigmoid Colon Which Clinically Simulated Cancer but Which Responded to Aureomycin Therapy

AMA Arch Intern Med. 1951;88(5):685-691. doi:10.1001/archinte.1951.03810110137012

ADISCUSSION of the etiological basis for benign granulomatous lesions of the rectum and sigmoid colon usually includes lymphogranuloma venereum, syphilis, tuberculosis, amebiasis, gonorrhea, and schistosomiasis.1 One encounters infrequently such lesions in a medical ward in a general hospital or in the practice of internal medicine. The differential diagnosis between a benign and a carcinomatous lesion is sometimes difficult. In view of this fact we thought it important to record our experience with two patients who presented this problem.

Two cases of granulomatous lesion of the rectum and sigmoid have been observed. From historical data and the results of physical examination, including proctosigmoidoscopy, the lesions were thought to be malignant, but after thorough study, including biopsy, they were proved to be nonspecific granulomas. The response of these lesions to aureomycin therapy was unexpected and most unusual and saved the patients from a resection of the colon and rectum that would