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Article
December 1951

RATIONALE OF THERAPEUTIC USE OF STREPTOKINASE-STREPTODORNASE IN AMEBIC ABSCESS OF LIVER

AMA Arch Intern Med. 1951;88(6):752-759. doi:10.1001/archinte.1951.03810120053004
Abstract

IT HAS been previously pointed out1 that the therapeutic effectiveness associated with the local instillation or application of the streptococcal enzymatic solutions of streptokinase-streptodornase2 is closely proportional to the fulfilment of the following principles:

  1. The exudative substances present in areas of disease must be composed of materials that are wholly or in part subject to the liquefying action of streptokinase and/or streptodornase.

  2. Direct and sustained contact must be made between the enzymatic solution and the total area of disease, followed by thorough evacuation of the thinned exudate and repetitions of the process if indicated.

It is the purpose of this presentation to describe the results obtained on a patient with an amebic abscess of the liver who was treated locally by repeated instillations of streptokinase-streptodornase, associated with appropriate drainage, and to demonstrate particularly the applicability of the principles indicated above.

REPORT OF A CASE  Patient B.

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