SINCE the introduction of antibiotics, considerable progress has been made in the treatment of subacute bacterial endocarditis. From the period of almost hopeless prognosis which prevailed before 1944 advance has been made to the stage where about 80% of the persons ill with this disease may be expected to respond successfully to treatment. Penicillin, the agent first used successfully, remains the most widely used and the drug of choice. Efforts to reduce the failure rate further have been directed mainly to a search for other antibiotics with wider or different spectrums of antibacterial activity. Reports of the use of streptomycin and aureomycin have appeared in the literature and indicate some degree of success. Another approach to the reduction of the failure rate is the use of combinations of antibiotics to take advantage of a possible additive or synergistic effect.
The first report of synergism between recent antibacterial agents appeared soon
WALLACH R, POMERANTZ N. COMBINED ANTIBIOTIC THERAPYReport of a Case of Subacute Bacterial Endocarditis Reinfected with a Diphtheroid and Successfully Treated with Penicillin and Bacitracin. AMA Arch Intern Med. 1951;88(6):840–846. doi:10.1001/archinte.1951.03810120141015
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