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January 1952

The Central Nervous System During Insulin Shock, with Special Reference to Structural Activity Changes of the Nerve Cells: An Experimental Histological Study.

AMA Arch Intern Med. 1952;89(1):168-169. doi:10.1001/archinte.1952.00240010178027

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The author presents a monographic study of the histological changes of the central nervous system in rabbits treated with insulin shock. Particular attention was given to the study of nerve cells in which, in the author's opinion, structural activity changes can be demonstrated very exactly by Einarson's "gallocyanin-chromalum staining" method. The author gives a good review of the literature of earlier experimental studies and casuistic publications. He then proceeds to discuss his personal investigations on rabbits, describing the clinical picture characterized by a coma, lasting for one or more hours during which two to six attacks of tonic-clonic convulsions developed. Einarson's method for the staining of the chromatin substances is, according to the author, far superior to the Nissl stain, which he declares is "absolutely unfit for sections from the central nervous system in which the Nissl picture is to be used in the evaluation of the activity changes of

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