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February 1952

VIREMIA IN ACUTE HEMOLYTIC ANEMIA AND IN AUTOHEMAGGLUTINATION: Report of a Case and Review of the Literature, with Special Reference to the Virus of Newcastle Disease

AMA Arch Intern Med. 1952;89(2):270-292. doi:10.1001/archinte.1952.00240020102007

THE LITERATURE dealing with acute hemolytic anemia increases considerably each year, but, notwithstanding the wealth of published case histories and speculations about the cause of the disease, it presents many unsolved problems. In the case to be reported the clinical picture was similar in many respects to that in cases already published, but this case is outstanding in the fact that a virus was isolated and identified as that of Newcastle disease. From studies based on this case much information was obtained indicating the part played by hemagglutinating viruses in hemolytic syndromes, and this paper presents a summary of the evidence obtained thus far, with special reference to the virus of Newcastle disease.

Despite the world-wide incidence of Newcastle disease as an acute and highly fatal infection of various species of birds,1 few instances of infection by the virus have been detected in man and other species of mammal.