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Article
April 1952

FOLLICULAR LYMPHOMA WITH TRANSIENT LEUKEMIC PHASEBrief Review of Literature and Report of a Case

AMA Arch Intern Med. 1952;89(4):621-634. doi:10.1001/archinte.1952.00240040100012
Abstract

ABRIEF review of the literature on blood changes in follicular lymphoma disclosed that in the cases reported by Brill, Baehr, and Rosenthal1 the blood picture was normal. The majority of later cases also appeared to be associated with normal red blood cell count and hemoglobin values. Sometimes slight anemia was observed.2 According to Gall and associates,3 anemia (a count of 3,500,000 red blood cells or less) was found in 18% of their 63 follicular lymphoma cases, compared with an incidence of 39% in their cases of other lymphomas. They frequently noted anemia as a terminal manifestation, perhaps due to long-continued irradiation. Meyer4 reported marked anemia in one of six cases; moderate anemia in two, and no anemia in three cases. Mayer and Thomas5 found terminal normocytic anemia in all their cases. The anemia was severe in only two cases. One patient, with normal results on bone marrow study, reacted well

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