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July 1952

ALLERGY—CORTICOTROPIN AND CORTISONE: A Review of the Literature from September, 1950, to January, 1952

Author Affiliations


From the Allergy Clinic, Massachusetts General Hospital.

AMA Arch Intern Med. 1952;90(1):96-127. doi:10.1001/archinte.1952.00240070102011

THE REVIEW of the literature on allergy from August, 1948, to September, 1950, which was published in April, 1951, by one of us,1 discussed the nature and the actions of corticotropin (ACTH) and cortisone in their broad aspects. Since then, there have been many new studies, for the remarkable effects of these drugs have made them the object of major interest in the clinic as well as in the laboratory. Let us look first at the results of laboratory studies.


The Effect of Corticotropin and Cortisone on Immune Processes  In regard to the effect of corticotropin and cortisone on immune processes, the possibilities are several: The adrenal cortical hormone may act by inhibiting the formation of antibodies, or perhaps by inhibiting the action of those already formed. It may prevent the union of antibody with antigen; it may alter the chemical effector which results from that union,