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Article
October 1952

CONTROLLED HYPOXEMIA TEST FOR CORONARY INSUFFICIENCY EMPLOYING THE MILLIKAN OXIMETERA Study of Normal and Abnormal Responses

AMA Arch Intern Med. 1952;90(4):435-443. doi:10.1001/archinte.1952.00240100012002
Abstract

THE DIAGNOSIS of coronary artery disease in the presence of a normal resting electrocardiogram has been aided by the use of tests designed to create a relative hypoxemia of the myocardium, the best known of which are the Master two-step test1 and the anoxemia test of Levy.2 The former method relies upon a standardized amount of exercise based on age, weight, and sex to create a greater demand for oxygen by the myocardium, whereas the anoxemia test decreases the amount of oxygen to the heart through the inhalation of a 10% oxygen mixture for a 20-minute period. The electrocardiographic changes which occur with these procedures in the presence of coronary disease are reflected mainly by RS-T segment depressions and/or T wave inversions in one or several leads. These alterations are similar in both tests and are thought to be due to factors common to the effects of exercise

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