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December 1952


AMA Arch Intern Med. 1952;90(6):869-878. doi:10.1001/archinte.1952.00240120144012

COCCIDIOIDOMYCOSIS in the disseminated form may involve any organ of the body with perhaps the exception of the epithelium of the gastrointestinal tract. Extensive involvement of the adrenal glands has been noted on many occasions at autopsy. In a series of 50 cases of disseminated coccidioidomycosis studied at autopsy by Forbes and Bestebreurtje, adrenal involvement was noted in 16.1 It is a fact of historical interest that in the first case of coccidioidal granuloma described by Rixford in 1893 the adrenal glands were found at autopsy to be... the size of turkey's eggs, and on section were seen to contain great masses of necrotic tissue with nuclear degeneration resembling that in chronic tuberculosis, with empty shells of the organism; living organisms in the periphery.2

However, in view of the frequency of adrenal involvement in chronic disseminated coccidioidomycosis, it is a singular fact that Addison's disease due to destruction

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