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February 1953

SECONDARY TUMORS OF HEART AND PERICARDIUM: Review of the Subject and Report of One Hundred Thirty-Seven Cases

Author Affiliations


From the Cardiovascular-Renal Section (Major DeLoach) and the Pathology Section (Major Haynes), Walter Reed Army Hospital, Walter Reed Army Medical Center, Washington, D. C.

AMA Arch Intern Med. 1953;91(2):224-249. doi:10.1001/archinte.1953.00240140084007

HEKTOEN,1 in 1893, while reporting two cases of secondary tumors of the heart, stated that 110 such cases had already been recorded. Despite this relatively impressive number and the numerous reports since that time, the recent literature contains references to the considered rarity of these tumors (Fischer,2 Lymburner3). Several lengthy statistical reports on the subject have appeared in the literature since the turn of the century (Peters and Milne,4 Morris,5 Yater,6 Hamilton,7 Pollia and Gogol,8 Scott and Garvin,9 Lisa and associates,10 Prichard11). Siegel and Young,12 in 1933, reported 3 cases of metastatic tumors in 44 cases of malignant disease (7.4%) among 592 autopsies. Burke,13 in 1934, in an analysis of 327 autopsies for malignant disease, observed 14 instances of metastatic involvement of cardiac muscle (4.3%). In the same year, Lymburner3 noted 52 secondary tumors of the heart in a review of 8,550 autopsies at the Mayo Clinic (0.6% for all

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