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Article
March 1953

INFECTIOUS DISEASESEighteenth Annual Review of Sifnificant Publications

AMA Arch Intern Med. 1953;91(3):353-388. doi:10.1001/archinte.1953.00240150072008
Abstract

DURING the past year, as usual, contributions to knowledge in the field of infectious disease covered a wide variety of interests. Antibiotic and chemotherapeutic agents were the subjects of most importance. Further evaluation of dosage and of the therapeutic effects were made of agents now available, and new antibiotics were introduced. Studies are in progress to test the value of newly introduced chemical compounds for the treatment of tuberculosis, malaria, amebiasis, and other diseases. Much attention was given to the untoward results of therapy with antibiotics, such as toxic or allergic reactions and the replacement of antibioticsensitive microbes with antibiotic-resistant ones. Retrospective investigation revealed the cause of a number of puzzling epidemics of pneumonia and others of encephalitis observed several years ago. The value of prophylactic vaccination against rabies was questioned. Large-scale projects are under way in many countries to vaccinate against tuberculosis. In the United States gamma globulin was

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