THE CONCEPT of myelofibrosis as a disease entity has been controversial for many years. Much debate has centered around its classification and terminology. Diseases which fit the currently recognized syndrome are to be found in the literature under many names. Descriptive terms such as myeloid metaplasia, myelosis, osteosclerosis, agnogenic myeloid metaplasia, pseudoleukemia, hepatosplenomegaly, erythroblastosis, and myelofibrosis have been used to represent the same process.1 Myelofibrosis generally has been accepted in this institution as the preferable term for this syndrome because of its descriptive proximity to the pathological process.
The object of this paper is to report eight cases we have observed over the last four years and to discuss the clinical and laboratory features that constitute this syndrome.2 In these cases the clinical diagnosis was confirmed by surgical biopsy of the bone marrow, splenic aspiration, postmortem examination, or combinations of the three procedures.
The syndrome of myelofibrosis
COOK JE, FRANKLIN JW, HAMILTON HE, FOWLER WM. SYNDROME OF MYELOFIBROSIS: Report of Eight Cases. AMA Arch Intern Med. 1953;91(6):704–714. doi:10.1001/archinte.1953.00240180013002
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