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Article
June 1953

SYNDROME OF MYELOFIBROSIS: Report of Eight Cases

Author Affiliations

IOWA CITY

From the Hematology Section, Department of Internal Medicine, University Hospitals and the State University of Iowa Medical School.

AMA Arch Intern Med. 1953;91(6):704-714. doi:10.1001/archinte.1953.00240180013002
Abstract

THE CONCEPT of myelofibrosis as a disease entity has been controversial for many years. Much debate has centered around its classification and terminology. Diseases which fit the currently recognized syndrome are to be found in the literature under many names. Descriptive terms such as myeloid metaplasia, myelosis, osteosclerosis, agnogenic myeloid metaplasia, pseudoleukemia, hepatosplenomegaly, erythroblastosis, and myelofibrosis have been used to represent the same process.1 Myelofibrosis generally has been accepted in this institution as the preferable term for this syndrome because of its descriptive proximity to the pathological process.

The object of this paper is to report eight cases we have observed over the last four years and to discuss the clinical and laboratory features that constitute this syndrome.2 In these cases the clinical diagnosis was confirmed by surgical biopsy of the bone marrow, splenic aspiration, postmortem examination, or combinations of the three procedures.

DEFINITION  The syndrome of myelofibrosis

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