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June 1953

Morbus Alzheimer and Morbus Pick: A Genetic, Clinical and Patho-Anatomical Study.

AMA Arch Intern Med. 1953;91(6):818-819. doi:10.1001/archinte.1953.00240180127021

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This monograph is divided in 3 parts, each of which is reviewed in a separate paragraph.

T. Sjögren has arrived at the surprising conclusion that about 10% of all presenile and senile psychoses fall under the diagnosis of Pick's or Alzheimer's disease. The average age at which these diseases begin and at death is about the same in patients with either disease, and the duration of the diseases is also the same (based on material of 80 cases). The genetic statistical analysis shows a predominant likelihood of multifactorial inheritance for Alzheimer's disease. For Pick's disease the hypothesis of a major gene with modifying genes appears more acceptable. In both diseases there is a predilection for women, a fact not explainable by a totally or partially sex-linked inheritance.

H. Sjögren's clinical analysis of 80 cases shows that aspontaneity in Stage I is predominant in both diseases. Moria and pronounced ethical defects

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