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August 1953

Chemical Induction of Cancer.

AMA Arch Intern Med. 1953;92(2):297-298. doi:10.1001/archinte.1953.00240200147024

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This little volume of 250 pages is a very readable account of the development of and our present concepts of the chemistry of experimental cancer. It is comprehensive in its scope, and, as Alexander Haddow states in his foreword, there is a "strong demand for some authoritative description of developments which would be of value to the general medical and scientific reader and to the interested layman." This book serves, indeed, the needs of the general medical and scientific reader, but the layman, unfamiliar with terminology and techniques, may become ensnared in hydrogen chains or alicyclic rings essential to the portrayal of the chemical structure of the known carcinogenic compounds.

The author gives comprehensive consideration to the polycyclic hydrocarbons and their heterocyclic analogues and to the sterols and bile acid compounds, all of which are known to be tumorigenic. Changes in the biologic activity of a given carcinogen, induced by

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